The USP44 antibody from Wuhan Fine Biotech Co., Ltd. is a Rabbit Polyclonal antibody to USP44. This antibody recognizes Homo Sapiens, and Human antigen. The USP44 antibody has been validated for the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome(APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex(also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B(H2BK120ub1) ubiquitination